Patient-identified Most Bothersome Symptom in Patients with Chronic Migraine: An Analysis of PROMISE-2
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Key messages
- Patients with migraine experience a wide variety of headache and non-headache symptoms that can occur at any point during a migraine attack, and the symptoms extend beyond the most often recognized ICHD-3 diagnostic criteria.
- The unique patient-identified most bothersome symptom measure captured in PROMISE-2 may be one method of quantifying disease- and treatment-related effects in patients with migraine.
- These results underscore the need to examine the impact of these additional symptoms, as well as evaluate thresholds for clinically meaningful reduction.
Presenting Author
Richard B. Lipton, MD
Professor and Vice Chair of Neurology
Albert Einstein College of Medicine
Bronx, New York
Richard B. Lipton, M.D., is the Edwin S. Lowe Professor and Vice-Chair of Neurology, Professor of Epidemiology and Population Health and Professor of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine, where he directs the Montefiore Headache Center. He is a diplomate of the American Board of Psychiatry and Neurology and a fellow of the American Academy of Neurology and UCNS certified in headache medicine.
Dr. Lipton’s headache research focuses on the epidemiology of migraine and on clinical trials. He has published over 900 articles in indexed journals and serves on the editorial boards of several journals, including Neurology. He is a five-time winner of the H.G. Wolff Award for excellence in headache research from the American Headache Society (AHS) and a two-time winner of the Enrico Greppi award from the European Headache Federation. He is a Past-President of the AHS and co-directs the Next Generation Migraine Therapy course for AHS.
Dr. Lipton earned his medical degree at the University of Chicago Pritzker School of Medicine. He completed a medical internship at Northwestern Memorial Hospital, his neurology residency and clinical neurophysiology fellowship at the Albert Einstein College of Medicine, and a fellowship in neuroepidemiology at Columbia University.
Presenter disclosures
Richard B. Lipton, MD: Alder (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Advisory board member) Allergan (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Advisory board member) American Academy of Neurology (Consulting) (Consulting Fees (e.g., advisory boards)) American Headache Society (Other Activities) (Consulting Fees (e.g., advisory boards)) Amgen (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Advisory board member) Autonomic Technologies (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Avanir (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Biohaven (Other Activities) (Stock Shareholder (excluding mutual funds))Biovision (Consulting) (Consulting Fees (e.g., advisory boards)) Boston Scientific (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Cephalalgia (Board Membership) (Other Financial or Material Support, Editorial board) Dr. Reddy’s (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) ElectroCore (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Eli Lilly (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) eNeura Therapeutics (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Stock Shareholder (excluding mutual funds), Advisory board member)GlaxoSmithKline (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Headache (Board Membership) (Other Financial or Material Support, Senior Advisor)Informa (Other Activities) (Other Financial or Material Support, Royalties from editorial or book publishing) Merck(Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Migraine Research Foundation (Other Activities) (Research Grant or Support)National Headache Foundation (Other Activities) (Research Grant or Support)Neurology (Board Membership) (Other Financial or Material Support, Editorial board) NIA(Other Activities) (Other Financial or Material Support, Reviewer) NIH (Other Activities) (Research Grant, Research Grant or Support) NINDS (Other Activities) (Other Financial or Material Support, Reviewer) Novartis (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Pernix (Consulting) (Consulting Fees (e.g., advisory boards)) Pfizer (Consulting) (Consulting Fees (e.g., advisory boards)) Supernus (Consulting) (Consulting Fees (e.g., advisory boards))Teva (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member)Trigemina (Consulting) (Consulting Fees (e.g., advisory boards)) Vector (Consulting) (Consulting Fees (e.g., advisory boards)) Vedanta (Other Activities) (Consulting Fees (e.g., advisory boards), Honoraria, Other Financial or Material Support, Advisory board member) Wolff’s Headache (Other Activities) (Other Financial or Material Support, Royalties from editorial or book publishing)
